In order to be able to use the short-cut keys you must go to Top Menu > Character > Personal > Tick "Use short-cut keys in combat" > Save
Manual hits:
Up - 
Q / 
↑ (up)
Middle - 
W / 
→ (right)
Down - 
E / 
↓ (down)
Skip Hit - 
SPACE bar
Block - 
R / 
← (left)
Change Mode - 
Tab
Mage Spells (11+):
Spell 1 - 
Q
Spell 2 - 
W
Spell 3 - 
E
Spell 4 - 
R
Spell 5 - 
T
Spell 6 - 
A
Spell 7 - 
S
Spell 8 - 
D
Spell 9 - 
F
Spell 10 - 
G
High Mage Spells (16+):
Magic 1 - 
T
Magic 2 - 
Y
Magic 3 - 
U
Magic 4 - 
I
Battle Slots:
Slot 1 - 
1 
Slot 2 - 
2
Slot 3 - 
3
Slot 4 - 
4
Slot 5 - 
5
Slot 6 - 
6
First Page slots - 
[
Second Page slots - 
] (apply for players having above 6 slots)
Note: When you shift the Page of slots the countdown is again from 1 to 6.
Miscellaneous:
Combat Backpack - 
B
Mount - 
M (apply on the last summoned/ridden mount)
Select yourself in the list of the battle - 
Z
Select an enemy in the list of the battle - 
X
Reset the selection - 
Ecs